Lisa Coles, MS, PhD
Titles
Education
NA
Biography
Bio
Dr. Coles is an Associate Director of Clinical Pharmacology and Pharmacometrics at the Center for Orphan Drug Research (CODR) at the University of Minnesota College of Pharmacy.
Dr. Coles earned a BS in Chemical Engineering from Iowa State University in 1996 and a MS in Biomedical Engineering from the University of Minnesota in 1998. Upon graduation, she accepted a position as a biochemical pharmacologist at 3M Pharmaceuticals where she worked for over 4 years conducting pharmacokinetic and drug metabolism studies. In 2003, Dr. Coles was accepted into the Pharmaceutical Sciences Department at the University of Maryland and received a PhD in 2008 in pharmacokinetics and pharmacodynamics. Her focus of her project was to evaluate the effect of pregnancy on drug distribution using a gravid mouse model and in vitro cell-based assays.
Research Summary
Dr. Coles research focuses on pharmacokinetics and pharmacodynamics of drugs for the treatment of rare neurological disorders such as neurodegenerative diseases and epilepsy syndromes.
Publications
Lessons from the Established Status Epilepticus Treatment Trial.
Cock HR, Coles LD, Elm J, Silbergleit R, Chamberlain JM, Cloyd JC, Fountain N, Shinnar S, Lowenstein D, Conwit R, Bleck TP, Kapur J.Epilepsy Behav. 2019 Dec;101(Pt B):106296. doi: 10.1016/j.yebeh.2019.04.049. Epub 2019 Oct 22.PMID: 31653603
Rescue therapies for seizure emergencies: New modes of administration.
Maglalang PD, Rautiola D, Siegel RA, Fine JM, Hanson LR, Coles LD, Cloyd JC.Epilepsia. 2018 Oct;59 Suppl 2:207-215. doi: 10.1111/epi.14479. Epub 2018 Aug 29.PMID: 3015989
Coles LD, Tuite PJ, Öz G, Mishra UR, Kartha RV, Sullivan KM, Cloyd JC, Terpstra M.J Clin Pharmacol. 2018 Feb;58(2):158-167. doi: 10.1002/jcph.1008. Epub 2017 Sep 22.PMID: 28940353
Coles LD, Tuite PJ, Öz G, Mishra UR, Kartha RV, Sullivan KM, Cloyd JC, Terpstra M.J Clin Pharmacol. 2018 Feb;58(2):158-167. doi: 10.1002/jcph.1008. Epub 2017 Sep 22.PMID: 28940353
Sathe AG, Tillman H, Coles LD, Elm JJ, Silbergleit R, Chamberlain J, Kapur J, Cock HR, Fountain NB, Shinnar S, Lowenstein DH, Conwit RA, Bleck TP, Cloyd JC.Acad Emerg Med. 2019 Aug;26(8):940-943. doi: 10.1111/acem.13811. Epub 2019 Jul 18.PMID: 31161706
Moheet A, Kumar A, Zhang Y, Eberly L, Coles LD, Seaquist ER.Endocrinol Diabetes Metab. 2020 May 15;3(3):e00144. doi: 10.1002/edm2.144. eCollection 2020 Jul.PMID: 32704565
Sathe AG, Tuite P, Chen C, Ma Y, Chen W, Cloyd J, Low WC, Steer CJ, Lee BY, Zhu XH, Coles LD.J Clin Pharmacol. 2020 Jun;60(6):744-750. doi: 10.1002/jcph.1575. Epub 2020 Feb 12.PMID: 32052462
Rautiola D, Maglalang PD, Cheryala N, Nelson KM, Georg GI, Fine JM, Svitak AL, Faltesek KA, Hanson LR, Mishra U, Coles LD, Cloyd JC, Siegel RA.J Pharmacol Exp Ther. 2019 Sep;370(3):796-805. doi: 10.1124/jpet.118.255943. Epub 2019 Mar 5.PMID: 30837282
Sathe AG, Elm JJ, Cloyd JC, Chamberlain JM, Silbergleit R, Kapur J, Cock HR, Fountain NB, Shinnar S, Lowenstein DH, Conwit RA, Bleck TP, Coles LD.Epilepsia. 2020 Jun;61(6):e66-e70. doi: 10.1111/epi.16534. Epub 2020 May 18.PMID: 32420641
Sathe AG, Mishra U, Ivaturi V, Brundage RC, Cloyd JC, Elm JJ, Chamberlain JM, Silbergleit R, Kapur J, Lowenstein DH, Shinnar S, Cock HR, Fountain NB, Babcock L, Coles LD.J Clin Pharmacol. 2020 Dec 17. doi: 10.1002/jcph.1801. Online ahead of print.PMID: 33336359
Intravenous Topiramate: Pharmacokinetics in Dogs with Naturally Occurring Epilepsy.
Vuu I, Coles LD, Maglalang P, Leppik IE, Worrell G, Crepeau D, Mishra U, Cloyd JC, Patterson EE.Front Vet Sci. 2016 Dec 5;3:107. doi: 10.3389/fvets.2016.00107. eCollection 2016.PMID: 27995128
Canine status epilepticus treated with fosphenytoin: A proof of principle study.
Patterson EE, Leppik IE, Coles LD, Podell M, Vite CH, Bush W, Cloyd JC.Epilepsia. 2015 Jun;56(6):882-7. doi: 10.1111/epi.12994. Epub 2015 May 7.PMID: 25953073
Pharmacokinetics and pharmacodynamics of intravenous baclofen in dogs: a preliminary study.
Scherkenbach LA, Coles LD, Patterson EE, Cloyd JC, Krach LE, Kriel RL.J Pharm Pharmacol. 2014 Jul;66(7):935-42. doi: 10.1111/jphp.12221. Epub 2014 Feb 13.PMID: 24697865
Schmitz NS, Krach LE, Coles LD, Mishra U, Agarwal SK, Cloyd JC, Kriel RL.PM R. 2017 Aug;9(8):743-750. doi: 10.1016/j.pmrj.2016.11.002. Epub 2016 Nov 17.PMID: 27867020
Zhou J, Coles LD, Kartha RV, Nash N, Mishra U, Lund TC, Cloyd JC.J Pharm Sci. 2015 Aug;104(8):2619-26. doi: 10.1002/jps.24482. Epub 2015 Jun 5.PMID: 26052837
Feasibility study of a caregiver seizure alert system in canine epilepsy.
Coles LD, Patterson EE, Sheffield WD, Mavoori J, Higgins J, Michael B, Leyde K, Cloyd JC, Litt B, Vite C, Worrell GA.Epilepsy Res. 2013 Oct;106(3):456-60. doi: 10.1016/j.eplepsyres.2013.06.007. Epub 2013 Aug 18.PMID: 23962794
Agarwal SK, Kriel RL, Cloyd JC, Coles LD, Scherkenbach LA, Tobin MH, Krach LE.J Child Neurol. 2015 Jan;30(1):37-41. doi: 10.1177/0883073814535504. Epub 2014 Jul 14.PMID: 25028414
Coles LD, Leppik IE, Patterson EE, Rivers Z, Mishra U, Cloyd JC.Epilepsia. 2015 Jun;56(6):888-94. doi: 10.1111/epi.12961. Epub 2015 May 7.PMID: 25952988